Factors evaluation of Oxidant – Antioxidant Malondialdehyde, plasma total antioxidant and Vitamin C in type 1 diabetes patients

Background: One of the most important diseases which is prevalent and chronic is Diabete. The conditions of oxidative stress and missing equilibrium of antioxidants have an important and main role in emerging and development of this disease. Evaluating the factors of oxidant – antioxidant Malondialdehyde, plasma total antioxidant and Vitamin C in type 1 diabetes patients is the main purpose of the present study. Methods: In the present case – control study, 30 patients suffering from type 1 diabetes were compared with 30 healthy persons. The capacity of plasma total antioxidant was measured with FRAP method. Malondialdehyde (MDA) was measured as final production of lipids peroxidation based on Hadley and Draper method and evaluation of vitamin C level using Roe and Queter method. Statistical analysis was done using T statistical test and SPSS soft ware. P <0.05 was considered as significant level. Results:The mean and standard deviation of vitamin C level in persons with case 7.43±0.67 was µmol/L and in persons with control 8.76±2.86 was µmol/L that statistically was significant (p = 0 .000). The capacity of plasma total antioxidant (TAC) and the amount of MAD as a factor lipids peroxidation  have a significant change in the two groups. Conclusion: In the present research, the level of antioxidant factors of vitamin C in patients suffering diabetes has been significantly less than control group. Therefore, it is recommended to consume and use natural antioxidants much more in order to reduce damages originate from free radicals.